Daniil Medvedev will begin his claycourt campaign on Wednesday when he takes on Alejandro Davidovich Fokina in the second round of the Mutua Madrid Open.
Medvedev, who returned a positive coronavirus test in Monte Carlo last month, has missed close to three weeks of tennis. But the Russian has made a full recovery, and he returned to action on a doubles court in the Spanish capital.
Joining forces with Brazil's Marcelo Demoliner, Medvedev knocked out the British pair of Dan Evans and Neal Skupski on Sunday.
Alejandro Davidovich Fokina, meanwhile, has already made his presence felt on European clay. The 21-year-old attained a significant milestone at Monte Carlo, where he reached the last eight of a Masters 1000 tournament for the first time in his career.
Davidovich Fokina took it a notch higher in Estoril, beating seasoned campaigners Pablo Andujar and Jeremy Chardy en route to the semifinals.
The Spaniard is making his second main-draw appearance at the Madrid Masters this year. He posted his maiden win at the tournament on Tuesday, taming Pierre-Hugues Herbert in a match featuring three tiebreak sets.
Daniil Medvedev and Alejandro Davidovich Fokina have never played each other before, so their head-to-head currently stands at 0-0.